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Editors' Choice

John F. Foley
3 April 2012: ec100.
During the starvation response, the I{kappa}B kinase IKK phosphorylates the regulatory subunit of PI3K, thus inhibiting PI3K activity. Abstract »  
Wei Wong
3 April 2012: ec101.
A Shigella flexneri effector deamidates a component of the NF-{kappa}B pathway to limit acute inflammatory responses. Abstract »  
L. Bryan Ray
3 April 2012: ec102.
Two proteins that regulate cell division also regulate sleep in Drosophila. Abstract »  
L. Bryan Ray
3 April 2012: ec103.
The effect of the drug rapamycin on life span can be separated from its effects on metabolism. Abstract »  



David M. Sabatini, Joseph A. Baur, and Annalisa M. VanHook
3 April 2012: pc7.
Rapamycin’s effects on longevity and insulin sensitivity are mediated by different molecular targets. Abstract »   Full Text »   Podcast »  


Research Articles

Fushun Wang, Nathan A. Smith, Qiwu Xu, Takumi Fujita, Akemichi Baba, Toshio Matsuda, Takahiro Takano, Lane Bekar, and Maiken Nedergaard
3 April 2012: ra26.
Astrocytes modulate synaptic activity by changing the local concentration of extracellular K+. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Misa Arizono, Hiroko Bannai, Kyoko Nakamura, Fumihiro Niwa, Masahiro Enomoto, Toru Matsu-ura, Akitoshi Miyamoto, Mark W. Sherwood, Takeshi Nakamura, and Katsuhiko Mikoshiba
3 April 2012: ra27.
An mGluR5-selective diffusion barrier enriches mGluR5 in astrocytic processes, enabling compartmentalized calcium signaling. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Takuya Akiyama, Guillermo Marqués, and Kristi A. Wharton
3 April 2012: ra28.
Mutations in an evolutionarily conserved processing site in bone morphogenetic proteins are associated with developmental disorders. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Aidan J. Peterson and Michael B. O’Connor
3 April 2012: pe14.
Alternative processing of ligands in the transforming growth factor–β family may fine-tune signaling outputs. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882