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Cover Figure

ONLINE COVER This week features a Research Article about a signaling complex that enables the compartmentalized regulation of cyclic AMP signaling by calcium entering through a specific channel. The image shows the effects of calcium released from internal stores on interactions between wild-type or mutant forms of proteins in this complex. [Image: Debbie Willoughby/University of Cambridge, United Kingdom]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882