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Editors' Choice

Nancy R. Gough
17 April 2012: ec109.
Axonal synthesis of SMADs triggered by the neurotrophin BDNF enables retrograde signaling by the morphogen BMP4 in trigeminal ganglia neurons. Abstract »  
Valda K. Vinson
17 April 2012: ec110.
Molecular dynamics simulations show how a voltage-gated channel closes. Abstract »  
Nancy R. Gough
17 April 2012: ec111.
By changing the abundance of the motor proteins, bacteria can adapt to differences in the abundance of the signaling protein. Abstract »  
Wei Wong
17 April 2012: ec112.
Increased angiogenesis in white adipose tissue can attenuate some of the metabolic effects of diet-induced obesity. Abstract »  
John F. Foley
17 April 2012: ec113.
Both insulin and Wnt signaling in preadipocytes depend on the Wnt co-receptor LRP5. Abstract »  
L. Bryan Ray
17 April 2012: ec114.
When the autophagy protein Atg7 is absent, nutrient withdrawal does not stop the cell cycle. Abstract »  
Stella M. Hurtley
17 April 2012: ec115.
The membrane scission and cytokinesis ESCRT machinery may help to protect against genetic damage. Abstract »  


Editorial Guides

Wei Wong and John F. Foley
17 April 2012: eg5.
Computational approaches can reveal how cells interpret, process, and respond to signals. Abstract »   Full Text »   PDF »  


Research Articles

Mitsuhiro Matsuda, Makito Koga, Eisuke Nishida, and Miki Ebisuya
17 April 2012: ra31.
An engineered system based on Notch and Delta in mammalian cultured cells recapitulates signal propagation, a phenomenon that occurs in development. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
David J. Klinke, II, Ning Cheng, and Emily Chambers
17 April 2012: ra32.
Combining experiments with mathematical modeling provides insights into the responses of T cells to cytokines. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Adrian L. Slusarczyk and Ron Weiss
17 April 2012: pe16.
Signal propagation through a synthetic gene circuit containing a cell contact–dependent positive feedback loop requires intracellular amplification. Abstract »   Full Text »   PDF »  
Rahul K. Das, Albert H. Mao, and Rohit V. Pappu
17 April 2012: pe17.
The application of a computational approach to identify short linear motifs may enable the engineering of signaling networks. Abstract »   Full Text »   PDF »  



Boris Kholodenko, Michael B. Yaffe, and Walter Kolch
17 April 2012: re1.
Signaling network construction and analysis provide insights into biology and medicine. Gloss »   Abstract »   Full Text »   PDF »  



Yue Li, Ryan J. Arsenault, Brett Trost, Jillian Slind, Philip J. Griebel, Scott Napper, and Anthony Kusalik
17 April 2012: pl2.
A new method of analysis of kinome data takes account of the differences between peptide arrays and DNA microarrays. Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882