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Editors' Choice

Nancy R. Gough
24 April 2012: ec116.
Morphine binds to and stimulates the TLR4-MD-2 complex to trigger neuroinflammatory responses. Abstract »  
Annalisa M. VanHook
24 April 2012: ec117.
Low light promotes the activity of a transcription factor that induces expression of genes required for auxin synthesis. Abstract »  
Nancy R. Gough
24 April 2012: ec118.
A glucose-induced alternative isoform of ChREBP, a transcription factor that promotes lipogenesis, may be a target for diabetes therapy. Abstract »  
Annalisa M. VanHook
24 April 2012: ec119.
The phosphorylation status of SCAR/WAVE drives pseudopod dynamics in chemotaxing cells. Abstract »  
Stella M. Hurtley
24 April 2012: ec120.
Conversion of a soluble prion protein to an aggregated state generates heritable resistance to antifungal drugs. Abstract »  


Journal Club

Maria S. Ioannou and Andrea L. Marat
24 April 2012: jc1.
The Eps15 homology domain promotes synaptic vesicle formation by limiting the extent of dynamin helix formation. Abstract »   Full Text »   PDF »  


Research Articles

Brandon Zimmerman, Alexandre Beautrait, Benjamin Aguila, Ricardo Charles, Emanuel Escher, Audrey Claing, Michel Bouvier, and Stéphane A. Laporte
24 April 2012: ra33.
Distinct conformational changes induced in β-arrestin determine whether angiotensin II analogs enhance β-arrestin–dependent proliferation or migration. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Andreas H. Guse
24 April 2012: pe18.
NAADP-mediated regulation of ion channels may occur through intermediary binding partners. Abstract »   Full Text »   PDF »  


Research Resources

Maor H. Pauker, Nirit Hassan, Elad Noy, Barak Reicher, and Mira Barda-Saad
24 April 2012: rs3.
The formation of a multiprotein complex in response to T cell activation is monitored in live cells. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882