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Editors' Choice

Wei Wong
1 May 2012: ec121.
The leucyl-tRNA synthetase acts as a leucine sensor for mTOR complex 1. Abstract »  
Annalisa M. VanHook
1 May 2012: ec122.
High CO2 induces cleavage and nuclear translocation of the transcription factor RelB. Abstract »  
Kristen Mueller
1 May 2012: ec123.
A human protein activates the assembly of a cellular complex that detects signs of infection. Abstract »  
L. Bryan Ray
1 May 2012: ec124.
Protein acetylation promotes autophagy in mammalian and yeast cells. Abstract »  
L. Bryan Ray
1 May 2012: ec125.
Bacteria adapting to growth in the presence of nitrate activate a transcriptional regulator also involved in oxidative stress. Abstract »  
Kristen Mueller
1 May 2012: ec126.
An inhibitory receptor is important for gut microflora containment by immunoglobulin A. Abstract »  



Hiroshi Suga and Annalisa M. VanHook
1 May 2012: pc9.
Receptor tyrosine kinases existed in the unicellular ancestors of multicellular animals and underwent diversification in the metazoan lineage. Abstract »   Full Text »   Podcast »  


Research Articles

Pinglong Xu, Jianming Liu, Masayo Sakaki-Yumoto, and Rik Derynck
1 May 2012: ra34.
A metalloproteinase implicated in inflammation and cancer is inactive as dimers and active as monomers. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Hiroshi Suga, Michael Dacre, Alex de Mendoza, Kamran Shalchian-Tabrizi, Gerard Manning, and Iñaki Ruiz-Trillo
1 May 2012: ra35.
A genomic survey suggests that cytoplasmic tyrosine kinases diversified before the establishment of multicellular organisms. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Keijo Viiri, Markku Mäki, and Olli Lohi
1 May 2012: pe19.
Phosphoinositides can promote or reduce the binding of proteins with roles in transcription to chromatin. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882