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Editors' Choice

Annalisa M. VanHook
15 May 2012: ec134.
A gene encoding a nuclear receptor coactivator split into two separate genes in the fly lineage. Abstract »  
John F. Foley
15 May 2012: ec135.
A systems-level analysis shows that, after their oncogenic signaling pathways are perturbed, tumor cells become more sensitive to DNA-damaging chemotherapy. Abstract »  
L. Bryan Ray
15 May 2012: ec136.
A Polycomb group protein regulates the cell cycle by promoting cyclin B ubiquitylation and degradation. Abstract »  
Annalisa M. VanHook
15 May 2012: ec137.
Polarized distribution of the myosin Dachs induces asymmetric cell contractions to drive tissue morphogenesis. Abstract »  
Ernesto Andrianantoandro
15 May 2012: ec138.
Nodal and Lefty dynamics in vivo provide biological evidence for Turing patterns. Abstract »  
Nancy R. Gough
15 May 2012: ec139.
Plasma membrane stress triggers redistribution of Slm proteins among distinct plasma membrane compartments to stimulate TORC2 activity and promote sphingolipid synthesis. Abstract »  
Guy Riddihough
15 May 2012: ec140.
An enzyme that binds to damaged DNA undergoes a structural reorganization that enhances its catalytic activity. Abstract »  



Jonathan M. Elkins and Stefan Knapp
15 May 2012: pe21.
The conformational changes caused by cAMP binding to the regulatory subunit in the PKA holoenzyme are shown. Abstract »   Full Text »   PDF »  
Ju Bao, Jie J. Zheng, and Dianqing Wu
15 May 2012: pe22.
Structural analysis indicates that the binding sites on a receptor for a ligand and an inhibitor partially overlap. Abstract »   Full Text »   PDF »  



Petronila Penela, Vanesa Lafarga, Olga Tapia, Verónica Rivas, Laura Nogués, Elisa Lucas, Rocío Vila-Bedmar, Cristina Murga, and Federico Mayor, Jr.
15 May 2012: pt3.
GRK2 modulates tubulin acetylation dynamics in an HDAC6-dependent manner to affect epithelial cell spreading and motility. Abstract »   Full Text »   PDF »   Slideshow »  


Research Resources

Kris C. Wood, David J. Konieczkowski, Cory M. Johannessen, Jesse S. Boehm, Pablo Tamayo, Olga B. Botvinnik, Jill P. Mesirov, William C. Hahn, David E. Root, Levi A. Garraway, and David M. Sabatini
15 May 2012: rs4.
Miniaturized functional genomics uncovers potentially useful combination therapies and drug targets for melanoma. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882