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Editors' Choice

John F. Foley
22 May 2012: ec141.
Neutrophils following a gradient of primary chemoattractant secrete leukotriene B4, generating a secondary gradient that enhances migration. Abstract »  
Nancy R. Gough
22 May 2012: ec142.
Cleavage and activation of the cation channel TRPC5 by calpains may contribute to growth cone collapse. Abstract »  
Peter R. Stern
22 May 2012: ec143.
Fly photoreceptors that detect colors also contribute information to the processing of motion. Abstract »  
Wei Wong
22 May 2012: ec144.
Fibroblast growth factor 1A enables remodeling of adipose tissue in response to changes in diet. Abstract »  
L. Bryan Ray
22 May 2012: ec145.
A possible molecular mechanism of action for a metabolite of aspirin is described. Abstract »  
Ernesto Andrianantoandro
22 May 2012: ec146.
Syndecan-2 enhancement of Notch signaling in smooth muscle cells may play a role in angiogenesis. Abstract »  
Ernesto Andrianantoandro
22 May 2012: ec147.
The receptor EphrinA2 promotes herpesvirus entry into endothelial cells. Abstract »  

 

Podcasts

Mari L. Shinohara and Annalisa M. VanHook
22 May 2012: pc11.
Interferon-β therapy is only effective in treating a mouse model of multiple sclerosis when the disease is dependent upon the NLRP3 inflammasome. Abstract »   Full Text »   Podcast »  

 

Research Articles

Makoto Inoue, Kristi L. Williams, Timothy Oliver, Peter Vandenabeele, Jayant V. Rajan, Edward A. Miao, and Mari L. Shinohara
22 May 2012: ra38.
Characterization of an animal model may explain why not all patients with multiple sclerosis respond to interferon-β. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Abby L. Parrill, Santiago Lima, and Sarah Spiegel
22 May 2012: pe23.
The lipid sphingosine 1-phosphate may laterally diffuse through the membrane to bind a receptor. Abstract »   Full Text »   PDF »  
Kozo Hamada and Katsuhiko Mikoshiba
22 May 2012: pe24.
Structural analyses suggest a similar gating mechanism in the IP3 and ryanodine receptors. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882