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Editors' Choice

Wei Wong
29 May 2012: ec148.
Preventing the phosphorylation of BAD switches the primary fuel source of neurons from glucose to ketone bodies. Abstract »  
Nancy R. Gough
29 May 2012: ec149.
Asymmetric engineered liposomes are antimicrobial and anti-inflammatory. Abstract »  
Ernesto Andrianantoandro
29 May 2012: ec150.
Tumor suppressor Nkx3.1 acts as an intercellular transcription factor. Abstract »  
Annalisa M. VanHook
29 May 2012: ec151.
PERK exhibits lipid kinase activity during the ER stress response and adipocyte differentiation. Abstract »  
Pamela J. Hines
29 May 2012: ec152.
A plant protein sensitive to blue light links longer afternoons to more flowering. Abstract »  
Sacha Vignieri
29 May 2012: ec153.
Neurons in a pigeon’s brain encode the direction and intensity of the geomagnetic field. Abstract »  


Editorial Guides

Wei Wong and Nancy R. Gough
29 May 2012: eg7.
Structural analyses of domains, proteins, and complexes provides insight into signaling mechanisms and uncovers therapeutic potential. Abstract »   Full Text »   PDF »  


Research Articles

Chao Xu, Jing Jin, Chuanbing Bian, Robert Lam, Ruijun Tian, Ryan Weist, Linya You, Jianyun Nie, Alexey Bochkarev, Wolfram Tempel, Chris S. Tan, Gregory A. Wasney, Masoud Vedadi, Gerald D. Gish, Cheryl H. Arrowsmith, Tony Pawson, Xiang-Jiao Yang, and Jinrong Min
29 May 2012: ra39.
Phosphorylation of a motif that binds to ankyrin repeat domains switches its binding preference to 14-3-3 proteins. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Henrik G. Dohlman and Janice C. Jones
29 May 2012: re2.
Structural studies suggest that the helical domain of G protein α subunits is an active participant in G protein signaling. Gloss »   Abstract »   Full Text »   PDF »  
Ryan Ferrao, Jixi Li, Elisa Bergamin, and Hao Wu
29 May 2012: re3.
Structural studies show that Toll-like receptors assemble into large oligomeric intracellular signaling complexes upon ligand binding. Gloss »   Abstract »   Full Text »   PDF »  



29 May 2012: er4.
A misstatement about the construct used in a highlighted paper is corrected. Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882