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Editors' Choice

Nancy R. Gough
5 June 2012: ec154.
Extracellular let-7 microRNA activates the innate immune receptor TLR7, triggering neuronal death. Abstract »  
L. Bryan Ray
5 June 2012: ec155.
The elusive enzyme that modifies proteins involved in building bone and teeth has now been identified. Abstract »  
John F. Foley
5 June 2012: ec156.
Under conditions of metabolic stress, tumor cells receive a survival advantage through AMPK-dependent maintenance of NADPH abundance. Abstract »  
Kristen L. Mueller
5 June 2012: ec157.
Restricted B cell signaling in the areas responsible for immune memory cell production promotes affinity maturation. Abstract »  
Pamela J. Hines
5 June 2012: ec158.
Structural analysis shows how fungus-derived chitin dimerizes its receptor on target plants and triggers defense responses. Abstract »  
Ernesto Andrianantoandro
5 June 2012: ec159.
Perturbation analysis reveals evolving connections between nodes in signaling networks underlying neutrophil polarization. Abstract »  
Valda K. Vinson
5 June 2012: ec160.
The structure of the amyloid precursor protein transmembrane domain allows processive cleavage and cholesterol binding that may enhance cleavage. Abstract »  


Research Articles

Flore Kruiswijk, Laurensia Yuniati, Roberto Magliozzi, Teck Yew Low, Ratna Lim, Renske Bolder, Shabaz Mohammed, Christopher G. Proud, Albert J. R. Heck, Michele Pagano, and Daniele Guardavaccaro
5 June 2012: ra40.
DNA damage triggers the phosphorylation of factors involved in protein synthesis to regulate polypeptide elongation. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Kshitiz, Maimon E. Hubbi, Eun Hyun Ahn, John Downey, Junaid Afzal, Deok-Ho Kim, Sergio Rey, Connie Chang, Arnab Kundu, Gregg L. Semenza, Roselle M. Abraham, and Andre Levchenko
5 June 2012: ra41.
Culturing cardiac precursors on a surface with the rigidity of heart tissue increases the yield of endothelial cells. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Sylvain Meloche and Philippe P. Roux
5 June 2012: pe25.
An inhibitor of protein synthesis is activated by DNA damage and degraded during recovery. Abstract »   Full Text »   PDF »  



Scott M. Carlson and Forest M. White
5 June 2012: pl3.
A strategy that uses analog-sensitive kinases enables the identification of low-abundance kinase substrates. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882