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Editors' Choice

Ernesto Andrianantoandro
12 June 2012: ec161.
The adaptor protein TRADD acts as a tumor suppressor by blocking a specific nuclear ubiquitylation event. Abstract »  
Nancy R. Gough
12 June 2012: ec162.
Aging-associated increases in complement C1q activate the Wnt pathway and compromise tissue regeneration. Abstract »  
Wei Wong
12 June 2012: ec163.
Nitric oxide and hydrogen sulfide signaling converge to promote cGMP-dependent processes in endothelial cells. Abstract »  
John F. Foley
12 June 2012: ec164.
A complex containing HIF-2α enables the translation of select mRNAs under hypoxic conditions when most protein synthesis is normally inhibited. Abstract »  
Kristen L. Mueller
12 June 2012: ec165.
Turning off the expression in the placenta of T cell attractants allows the mother to tolerate the fetus. Abstract »  
Kristen L. Mueller
12 June 2012: ec166.
Mammals contain resident fungal intestinal populations that influence disease susceptibility. Abstract »  
Kristen L. Mueller
12 June 2012: ec167.
Lymphocytes prevent bacteria from spreading beyond gut-associated lymphoid tissues and causing systemic inflammation. Abstract »  

 

Podcasts

Shawn M. Ferguson and Annalisa M. VanHook
12 June 2012: pc12.
Regulated nuclear translocation of a transcription factor maintains lysosomal homeostasis. Abstract »   Full Text »   Podcast »  

 

Research Articles

Agnes Roczniak-Ferguson, Constance S. Petit, Florian Froehlich, Sharon Qian, Jennifer Ky, Brittany Angarola, Tobias C. Walther, and Shawn M. Ferguson
12 June 2012: ra42.
The nuclear translocation of a transcription factor that promotes lysosomal biogenesis is inhibited when lysosomal function is adequate. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Yan Zou, Hui Chiu, Dorothée Domenger, Chiou-Fen Chuang, and Chieh Chang
12 June 2012: ra43.
A microRNA instructs neurons when to stop axonal pathfinding. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Ivan Gusarov and Evgeny Nudler
12 June 2012: pe26.
Bacteria respond to nitric oxide and oxygen in their environment using two different posttranslational modifications of the same transcription factor to promote expression of protective genes specific to each gas. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882