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Editors' Choice

Ernesto Andrianantoandro
19 June 2012: ec168.
Nicotine activates AMPK-α2, leading to abdominal aortic aneurysms in mice. Abstract »  
Wei Wong
19 June 2012: ec169.
Melanomas transfer various proteins, including the receptor MET, to bone marrow–derived cells through exosomes to promote metastasis. Abstract »  
John F. Foley
19 June 2012: ec170.
Two receptors for the plant hormone salicylic acid differentially determine cellular responses to infection. Abstract »  
Nancy R. Gough
19 June 2012: ec171.
Caspase-mediated cleavage of the channel TRPM7 enhances its activity and promotes Fas-mediated cell death. Abstract »  
Valda K. Vinson
19 June 2012: ec172.
After DNA damage, pulses of p53 allow recovery, whereas sustained levels lead to senescence. Abstract »  



Holly A. Ingraham, Raymond D. Blind, and Annalisa M. VanHook
19 June 2012: pc13.
Modification of a bound lipid modulates the activity of a nuclear receptor. Abstract »   Full Text »   Podcast »  


Research Articles

Raymond D. Blind, Miyuki Suzawa, and Holly A. Ingraham
19 June 2012: ra44.
The transcriptional activity of a nuclear receptor is regulated by the phosphorylation status of a bound lipid. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Ulf H. Beier, Liqing Wang, Rongxiang Han, Tatiana Akimova, Yujie Liu, and Wayne W. Hancock
19 June 2012: ra45.
Combined inhibition of distinct histone deacetylases enhances the suppressive effects of regulatory T cells. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Iswar K. Hariharan
19 June 2012: pe27.
An insulin-like peptide delays metamorphosis of the fruit fly in response to injury or tissue overgrowth. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882