19 June 2012
Vol 5, Issue 229

About The Cover

Cover image expansion

Online Cover This week features a Research Article that describes the regulation of the transcriptional activity of the nuclear receptor SF-1 by the phosphorylation status of a bound lipid, PIP2. The image shows a model of the SF-1–PIP2 complex, with a surface rendering of the lipid-binding pocket of SF-1 and a stick representation of PIP2, and is based on the crystal structure of phosphatidylcholine-bound SF-1. [Image: Raymond Blind/Department of Cellular and Molecular Pharmacology, University of California, San Francisco]