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Cover Figure

ONLINE COVER This week features a Research Article that describes the regulation of the transcriptional activity of the nuclear receptor SF-1 by the phosphorylation status of a bound lipid, PIP2. The image shows a model of the SF-1–PIP2 complex, with a surface rendering of the lipid-binding pocket of SF-1 and a stick representation of PIP2, and is based on the crystal structure of phosphatidylcholine-bound SF-1. [Image: Raymond Blind/Department of Cellular and Molecular Pharmacology, University of California, San Francisco]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882