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Editors' Choice

Annalisa M. VanHook
26 June 2012: ec173.
Wnt signaling through β-catenin promotes genetic stability by stimulating the production of telomerase. Abstract »  
John F. Foley
26 June 2012: ec174.
Virus-induced activation of RIG-I–like receptors suppresses Toll-like receptor–dependent antibacterial responses. Abstract »  
Ernesto Andrianantoandro
26 June 2012: ec175.
p53 induces necrosis in response to oxidative stress by opening the mitochondrial permeability transition pore. Abstract »  
Annalisa M. VanHook
26 June 2012: ec176.
BMPs induce a series of signaling events that control migration and specification of sympathetic neurons and adrenal medullary cells from a progenitor population. Abstract »  
Nancy R. Gough
26 June 2012: ec177.
By binding to two receptor tyrosine kinase subunits, dimeric Grb2 may enable basal receptor phosphorylation, while limiting downstream signaling. Abstract »  



Vassiliki A. Boussiotis and Annalisa M. VanHook
26 June 2012: pc14.
An inhibitory receptor blocks proliferation of autoreactive T cells to promote tolerance in the periphery. Abstract »   Full Text »   Podcast »  


Research Articles

Nikolaos Patsoukis, Julia Brown, Victoria Petkova, Fang Liu, Lequn Li, and Vassiliki A. Boussiotis
26 June 2012: ra46.
The inhibitory receptor PD-1 blocks T cell proliferation by preventing cells from leaving the G1 phase of the cell cycle. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Roland Willmann and Thorsten Nürnberger
26 June 2012: pe28.
A plant immune receptor is selectively activated by larger chitin fragments that trigger receptor dimerization. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882