Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Cover Figure

ONLINE COVER This week features a Research Article that examined how the inhibitory receptor PD-1 blocks the proliferation of activated human CD4+ T cells, thereby preventing the expansion of autoreactive T cells. By inhibiting Ras and Akt signaling pathways, PD-1 affected components of the cell cycle machinery to lock T cells in the G1 phase of the cell cycle and prevent their proliferation. The image shows a T cell. [Image: Dennis Kunkel Microscopy, Inc.]

[Table of Contents]


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882