ONLINE COVER This week features a Research Article that examined how the inhibitory receptor PD-1 blocks the proliferation of activated human CD4⁺ T cells, thereby preventing the expansion of autoreactive T cells. By inhibiting Ras and Akt signaling pathways, PD-1 affected components of the cell cycle machinery to lock T cells in the G₁ phase of the cell cycle and prevent their proliferation. The image shows a T cell. [Image: Dennis Kunkel Microscopy, Inc.]

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