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Editors' Choice

Nancy R. Gough
3 July 2012: ec178.
The Chlamydia protein YtgCR is cleaved to yield a metal permease and an iron-regulated transcriptional repressor. Abstract »  
Wei Wong
3 July 2012: ec179.
Prolyl isomerization reduces the abundance of the tumor suppressor Fbw7 by triggering its self-ubiquitination. Abstract »  
Nancy R. Gough
3 July 2012: ec180.
Phosphorylation-stimulated SUMOylation of the estrogen receptor β prevents receptor degradation but also reduces promoter binding. Abstract »  
Ernesto Andrianantoandro
3 July 2012: ec181.
A metabolic regulator also modulates immune cells in fatty tissue. Abstract »  
Pamela J. Hines
3 July 2012: ec182.
Crystal structures of plant GH3 proteins reveal how these enzymes accommodate jasmonates, auxins, and benzoates. Abstract »  



K. Christopher Garcia and Annalisa M. VanHook
3 July 2012: pc15.
Structural analysis reveals how a Wnt binds to its receptor. Abstract »   Full Text »   Podcast »  


Research Articles

Abu-Bakr Al-Mehdi, Viktor M. Pastukh, Brad M. Swiger, Darla J. Reed, Mita R. Patel, Gina C. Bardwell, Viktoriya V. Pastukh, Mikhail F. Alexeyev, and Mark N. Gillespie
3 July 2012: ra47.
Reactive oxygen species generated by mitochondria that redistribute near the nucleus promote transcriptional responses to hypoxia. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Ahmed Hamaï and Patrice Codogno
3 July 2012: pe29.
Yeast and mammals use protein acetylation to promote the formation of the autophagosome. Abstract »   Full Text »   PDF »  


Research Resources

Dinah Loerke, Quint le Duc, Iris Blonk, Andre Kerstens, Emma Spanjaard, Matthias Machacek, Gaudenz Danuser, and Johan de Rooij
3 July 2012: rs5.
Imaging analysis tools identify drugs that inhibit different aspects of cell scattering, which occurs in cancer cells. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882