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Cover Figure

ONLINE COVER This week features a Research Article that describes how reactive oxygen species generated by mitochondria that redistribute near the nucleus promote transcriptional responses to low oxygen concentrations (hypoxia). The image shows the hypoxia-induced redistribution of mitochondria (red) around nuclei (blue) in pulmonary artery endothelial cells. [Image: Abu-Bakr Al-Mehdi/University of South Alabama College of Medicine]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882