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Editors' Choice

Nancy R. Gough
10 July 2012: ec183.
Tumor cells use the chemokines CXCL1 and 2 to recruit myeloid cells that produce signals that enhance the tumor cells’ survival. Abstract »  
Wei Wong
10 July 2012: ec184.
An anion channel is a heat sensor in nociceptive neurons. Abstract »  
Ernesto Andrianantoandro
10 July 2012: ec185.
Engineering nonimmune cells with components of the T cell receptor signaling system enables the interaction with antigen-presenting cells to initiate T cell receptor activation. Abstract »  
John F. Foley
10 July 2012: ec186.
Selective autophagy of Bcl10 inhibits T cell receptor–dependent activation of the transcription factor NF-{kappa}B. Abstract »  
Valda K. Vinson
10 July 2012: ec187.
The structure of the morphogen Wnt bound to its receptor provides a basis for understanding Wnt’s functional pleiotropy. Abstract »  



Brendan D. Manning
10 July 2012: lc3.
Manning questions whether the biochemical readout used to test the network models is sufficiently specific. Abstract »   Full Text »   PDF »  
Piero Dalle Pezze, Annika G. Sonntag, Daryl P. Shanley, and Kathrin Thedieck
10 July 2012: lc4.
Dalle Pezze et al. respond to criticisms regarding the specificity of phosphorylation of Ser2481 of mTOR as a specific readout of mTORC2 activity. Abstract »   Full Text »   PDF »  


Research Articles

Vasilica Nache, Thomas Zimmer, Nisa Wongsamitkul, Ralf Schmauder, Jana Kusch, Lisa Reinhardt, Wolfgang Bönigk, Reinhard Seifert, Christoph Biskup, Frank Schwede, and Klaus Benndorf
10 July 2012: ra48.
Different subunits of olfactory CNG channels enable specific regulation of channel activity by cAMP or cGMP. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Hun Sik Kim and Eric O. Long
10 July 2012: ra49.
Targeted tyrosine phosphorylation of an adaptor protein is required for the synergistic activation of natural killer cells by distinct pairs of receptors. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882