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Editors' Choice

Ernesto Andrianantoandro
31 July 2012: ec199.
Stromal cells produce factors that help cancer cells resist chemotherapy treatment. Abstract »  
Annalisa M. VanHook
31 July 2012: ec200.
The adaptor protein Sarm1 is required for Wallerian degeneration of damaged axons. Abstract »  
Nancy R. Gough
31 July 2012: ec201.
Monomeric Homer isoforms release receptors from multimeric Homer scaffolds to mediate synaptic modulation. Abstract »  
John F. Foley
31 July 2012: ec202.
Fusion of a virus with the host cell membrane acts as a danger signal to trigger an antiviral response dependent on the adaptor STING. Abstract »  
Stella M. Hurtley
31 July 2012: ec203.
Parasites release cyclic adenosine monophosphate when swallowed up by myeloid cells, thereby turning off a host defense pathway. Abstract »  
Kristen L. Mueller
31 July 2012: ec204.
Rather than killing bacteria directly, a gut antimicrobial peptide forms netlike structures that ensnare invading bacteria. Abstract »  

 

Editorial Guides

Ernesto Andrianantoandro and John F. Foley
31 July 2012: eg8.
Similar modes of regulation across different cell types promote effective innate and adaptive immunity. Abstract »   Full Text »   PDF »  

 

Podcasts

Susan K. Pierce and Annalisa M. VanHook
31 July 2012: pc17.
A scaffolding protein enables clustering of IgG B cell receptors to promote antibody secretion by memory B cells. Abstract »   Full Text »   Podcast »  

 

Research Articles

Wanli Liu, Elizabeth Chen, Xing Wang Zhao, Zheng Peng Wan, Yi Ren Gao, Angel Davey, Eric Huang, Lijia Zhang, Jillian Crocetti, Gabriel Sandoval, M. Gordon Joyce, Carrie Miceli, Jan Lukszo, L. Aravind, Wojciech Swat, Joseph Brzostowski, and Susan K. Pierce
31 July 2012: ra54.
A scaffolding protein clusters B cell receptors to enable the rapid, high-titer antibody responses of memory B cells. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Amisha Patel, Nicola Harker, Lara Moreira-Santos, Manuela Ferreira, Kieran Alden, Jon Timmis, Katie Foster, Anna Garefalaki, Panayotis Pachnis, Paul Andrews, Hideki Enomoto, Jeffrey Milbrandt, Vassilis Pachnis, Mark C. Coles, Dimitris Kioussis, and Henrique Veiga-Fernandes
31 July 2012: ra55.
Cis and trans signaling mechanisms direct different developmental responses to ligands for the receptor tyrosine kinase RET. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Fan Pan, Huimin Fan, Zhongmin Liu, and Shuiping Jiang
31 July 2012: pe32.
The PD-1 receptor in effector T cells and the transcription factor Foxp3 in Tregs are promising targets for therapies. Abstract »   Full Text »   PDF »  
Laurent P. Malherbe and Demin Wang
31 July 2012: pe33.
T cell migration requires phosphorylation of an adaptor protein by Abl family kinases to activate guanosine triphosphatase Rap1. Abstract »   Full Text »   PDF »  
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