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Editors' Choice

Wei Wong
7 August 2012: ec205.
SIRT-1–mediated deacetylation promotes the ability of PPAR{gamma} to induce the browning of white adipose tissue. Abstract »  
Nancy R. Gough
7 August 2012: ec206.
Lumen formation by mammary epithelial cells involves two distinct effects of cAMP signaling in the inner and outer cells. Abstract »  
Ernesto Andrianantoandro
7 August 2012: ec207.
The structure of follicle-stimulating hormone bound to the ectodomain of its receptor reveals a possible mechanism for receptor activation. Abstract »  
Stella M. Hurtley
7 August 2012: ec208.
When stressed, the mitochondrion reduces import of a transcription factor, which enters the nucleus instead. Abstract »  
L. Bryan Ray
7 August 2012: ec209.
A circadian rhythm regulator acts by altering the elongation stage of gene expression. Abstract »  
Pamela J. Hines
7 August 2012: ec210.
Arabidopsis adjusts the onset of flowering to the length of winters via an epigenetic mechanism. Abstract »  



Christopher W. Ward, Ramzi J. Khairallah, Eric P. Hoffman, and Annalisa M. VanHook
7 August 2012: pc18.
Drugs that reduce microtubule density or prevent the production of reactive oxygen species in skeletal muscle might slow the progression of Duchenne muscular dystrophy. Abstract »   Full Text »   Podcast »  


Research Articles

Ramzi J. Khairallah, Guoli Shi, Francesca Sbrana, Benjamin L. Prosser, Carlos Borroto, Mark J. Mazaitis, Eric P. Hoffman, Anup Mahurkar, Fredrick Sachs, Yezhou Sun, Yi-Wen Chen, Roberto Raiteri, W. Jonathan Lederer, Susan G. Dorsey, and Christopher W. Ward
7 August 2012: ra56.
Decreasing microtubule density in a mouse model of muscular dystrophy reduces contraction-induced muscle injury. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Céline Delloye-Bourgeois, David Goldschneider, Andrea Paradisi, Gabriel Therizols, Stéphane Belin, Sabine Hacot, Manuel Rosa-Calatrava, Jean-Yves Scoazec, Jean-Jacques Diaz, Agnès Bernet, and Patrick Mehlen
7 August 2012: ra57.
A nuclear-localized isoform of netrin may enhance ribosome biogenesis to promote cancer growth. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Dirk M. Hermann and Ayman ElAli
7 August 2012: re4.
Understanding brain vascular remodeling may allow effective intervention in cases of injury or disease that disrupt the blood-brain barrier. Gloss »   Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882