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Cover Figure

ONLINE COVER This week features a Research Article that shows that the protease Omi inhibits inflammation in microglial cells by inactivating a kinase upstream of extracellular signal–regulated kinases. Mutations in Omi that block its protease activity are associated with inflammation in Parkinson's disease. The image shows staining for a marker of activated astrocytes in a brain section from a mouse expressing protease-deficient Omi. [Image: Qingsong Hu, Chinese Academy of Sciences, Hefei, China]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882