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Editors' Choice

John F. Foley
21 August 2012: ec218.
G protein–coupled receptors can activate or inhibit the Hippo pathway in a G protein–dependent manner. Abstract »  
Wei Wong
21 August 2012: ec219.
In addition to binding to the adipokine apelin, the G protein–coupled receptor APJ responds to mechanical stretch. Abstract »  
Ernesto Andrianantoandro
21 August 2012: ec220.
EGF stimulation regulates alternative splicing by signaling through Akt and splicing factor kinases. Abstract »  
Laura M. Zahn
21 August 2012: ec221.
Rhinoceros beetle horns, a sexually selected weapon, are sensitive to nutrition and reliably indicate male quality. Abstract »  
L. Bryan Ray
21 August 2012: ec222.
Diurnal metabolic changes in circadian clock neurons are coupled to changes in potassium channel activity. Abstract »  


Research Articles

Maarten F. Bijlsma, Helene Damhofer, and Henk Roelink
21 August 2012: ra60.
Hedgehog stimulates a chemotactic or transcriptional response depending on the intracellular trafficking of the co-receptor Smoothened. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Qingsong Hu, Bin Li, Ranjie Xu, Dong Chen, Chenchen Mu, Erkang Fei, and Guanghui Wang
21 August 2012: ra61.
Loss of a protease in microglia results in neuroinflammation that contributes to neurodegeneration and Parkinson’s disease. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Chuwen Lin, Yoko Inès Nozawa, and Pao-Tien Chuang
21 August 2012: pe35.
Distinct outputs of Hedgehog signaling arise from different subcellular localization of the signal transducer Smoothened. Abstract »   Full Text »   PDF »  



21 August 2012: er5.
Mark Sevecka is added as an author of this Protocol. Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882