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Editors' Choice

Nancy R. Gough
28 August 2012: ec223.
The antiepileptic drug valproic acid reduces symptoms of a mouse model of multiple sclerosis by inhibiting T cell function. Abstract »  
Stella M. Hurtley
28 August 2012: ec224.
Two synaptic adhesion molecules that have been implicated in psychiatric diseases affect the kinetics of synaptic events. Abstract »  
L. Bryan Ray
28 August 2012: ec225.
Inhibition of a key metabolic enzyme reprograms metabolic flux toward pathways critical for cancer cell proliferation. Abstract »  
Annalisa M. VanHook
28 August 2012: ec226.
Cis-regulatory elements ensure that the expression domains of two patterning signals do not overlap. Abstract »  



Guanghui Wang and Annalisa M. VanHook
28 August 2012: pc20.
A protease can help protect against neurodegeneration by preventing inflammation in microglia. Abstract »   Full Text »   Podcast »  


Research Articles

Katja Jennissen, Franziska Siegel, Michaela Liebig-Gonglach, Michaela-Rosemarie Hermann, Stefanie Kipschull, Sander van Dooren, Wolfram S. Kunz, Reinhard Fässler, and Alexander Pfeifer
28 August 2012: ra62.
Targeting the cGMP effector VASP may enhance metabolism by stimulating the activity and abundance of brown adipocytes. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Keqiang Xie, Ikuo Masuho, Cameron Brand, Carmen W. Dessauer, and Kirill A. Martemyanov
28 August 2012: ra63.
By suppressing cAMP production in the striatum, the RGS9-2/Gβ5 complex could affect the development of opioid addiction. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Jean-Claude Henquin
28 August 2012: pe36.
The role of β cell taste receptors in the control of insulin secretion is unclear. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882