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ONLINE COVER This week features a Research Article that describes how mice lacking the cGMP effector VASP have a higher metabolism because of an increase in brown adipose tissue and the "browning" of white adipose tissue, a process in which white adipocytes acquire the characteristics of brown adipocytes. The image shows a cross section of white adipose tissue from VASP–/– mice stained for UCP-1, a protein that is highly abundant in brown adipose tissue. [Image: Eike Joeres and Ana Kilic/Institute of Pharmacology and Toxicology, University of Bonn]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882