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Editors' Choice

Ernesto Andrianantoandro
4 September 2012: ec227.
MicroRNAs released by tumor cells activate the JAK-STAT pathway in endothelial cells, leading to migration and angiogenesis. Abstract »  
Nancy R. Gough
4 September 2012: ec228.
In mice, a difference in nitric oxide concentration in the hippocampus between males and females appears to influence affective behavior. Abstract »  
John F. Foley
4 September 2012: ec229.
Activation of an ion channel that responds to cold temperature is inhibited by the direct association of a G protein α subunit. Abstract »  
Kristen L. Mueller
4 September 2012: ec230.
The skin microbiota play a selective role in modulating immunity in the skin of mice. Abstract »  
Wei Wong
4 September 2012: ec231.
Voltage-gated sodium channels enhance Ca2+ influx in response to nonself ligands and promote the development of CD4+ T cells. Abstract »  
Kristen L. Mueller
4 September 2012: ec232.
A region of ribosomal RNA that confers antibiotic resistance is also recognized by mouse innate immune receptors. Abstract »  
Wei Wong
4 September 2012: ec233.
A signaling molecule thought to be confined to prokaryotes promotes stalk formation in food-deprived Dictyostelium. Abstract »  
Ernesto Andrianantoandro
4 September 2012: ec234.
Stress induces JNK phosphorylation of a mitochondrial fusion protein, leading to its degradation, mitochondrial fragmentation, and apoptosis. Abstract »  
L. Bryan Ray
4 September 2012: ec235.
A small molecule binds to a core protein in the circadian clock and slows down time. Abstract »  


Research Articles

Priscila F. Siesser, Marta Motolese, Matthew P. Walker, Dennis Goldfarb, Kelly Gewain, Feng Yan, Rima M. Kulikauskas, Andy J. Chien, Linda Wordeman, and Michael B. Major
4 September 2012: ra64.
Unlike related proteins, FAM123A interacts with microtubule-associated proteins and alters microtubule dynamics. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Jerid W. Robinson and Lincoln R. Potter
4 September 2012: ra65.
An ATP-binding allosteric site could be pharmacologically targeted to alter the activity of membrane guanylyl cyclases. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Roland Seifert and Kerstin Y. Beste
4 September 2012: pe37.
Targeting allosteric rather than catalytic sites of nucleotidyl cyclases could result in isoform specificity. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882