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Editors' Choice

Nancy R. Gough
11 September 2012: ec236.
Trypanosoma brucei relies on a third TOR complex to limit differentiation from the proliferative to the quiescent form. Abstract »  
Wei Wong
11 September 2012: ec237.
JNK3 promotes the generation of β-amyloid and ER stress in Alzheimer’s disease. Abstract »  
Paula A. Kiberstis
11 September 2012: ec238.
A fusion gene detected in a small subset of human brain tumors encodes a potentially druggable target. Abstract »  
L. Bryan Ray
11 September 2012: ec239.
A scaffold protein controls signal transmission by using an autoinhibitory domain as a gate. Abstract »  
John F. Foley
11 September 2012: ec240.
Effector proteins from bacteria inhibit Rab1 to disrupt vesicular functions and block immune responses. Abstract »  
Stella M. Hurtley
11 September 2012: ec241.
A myosin thick filament–associated sarcomeric protein modulates cardiac contractility in a phosphorylation-dependent manner. Abstract »  
Valda Vinson
11 September 2012: ec242.
In rhodopsin, the transition state for thermal activation has the same electronic structure as that for photoexcitation. Abstract »  



Alissa M. Weaver and Annalisa M. VanHook
11 September 2012: pc21.
The activity of a lipid kinase influences the production of invadopodia by cancer cells. Abstract »   Full Text »   Podcast »  


Research Articles

Daisuke Hoshino, Jerome Jourquin, Shane Weller Emmons, Tyne Miller, Margalit Goldgof, Kaitlin Costello, Darren R. Tyson, Brandee Brown, Yiling Lu, Nagendra K. Prasad, Bing Zhang, Gordon B. Mills, Wendell G. Yarbrough, Vito Quaranta, Motoharu Seiki, and Alissa M. Weaver
11 September 2012: ra66.
The activity of the lipid kinase PI3K governs whether the protein kinase PKCα promotes invasive behavior of cancer cells. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Yong Juan Zhao, Connie Mo Ching Lam, and Hon Cheung Lee
11 September 2012: ra67.
The identification of two forms of a transmembrane enzyme suggests that flipping the catalytic domain from the outside to the inside of the cell may regulate its activity. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Davide Ruggero
11 September 2012: pe38.
Deregulations in ribosome biogenesis contribute to tumorigenesis and could be targeted to treat cancer. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882