Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Cover Figure

ONLINE COVER This week features a Research Article that describes how the activity of the lipid kinase PI3K governs whether the protein kinase PKCα promotes the formation of invadopodia in cancer cells (also listen to the accompanying Podcast). Invadopodia are cellular protrusions that can degrade the extracellular matrix and enhance the invasiveness of cancer cells. The image shows cells with invadopodia (red) and focal adhesions (green), cellular structures that contain many of the same components as invadopodia but have decreased ability to degrade the extracellular matrix. [Image: Daisuke Hoshino/Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Tokyo, Japan]

[Table of Contents]

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882