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Editors' Choice

John F. Foley
18 September 2012: ec243.
The dedifferentiation of pancreatic β cells into progenitor cells may underlie the development of type 2 diabetes. Abstract »  
Nancy R. Gough
18 September 2012: ec244.
The circadian regulator CLOCK enhances the transcriptional activity of the immune regulator NF-{kappa}B. Abstract »  
Annalisa M. VanHook
18 September 2012: ec245.
A kinase opposes Hippo signaling by promoting activity of the transcriptional coactivator Yorkie. Abstract »  
Valda Vinson
18 September 2012: ec246.
Spatial restraints revealed by chemical cross-linking and mass spectrometry elucidate the topology of a dynamic signaling network. Abstract »  
Pamela J. Hines
18 September 2012: ec247.
A Rho guanosine triphosphatase–based regulatory mechanism reveals how plants remodel membranes and cell walls to produce various cell shapes. Abstract »  
Stella M. Hurtley
18 September 2012: ec248.
Zippering of a single SNARE complex generates high force and energy that can potentially drive synaptic membrane fusion. Abstract »  



Michael P. Murphy
18 September 2012: pe39.
Hypoxia induces the redistribution of mitochondria to promote transcriptional responses to low oxygen. Abstract »   Full Text »   PDF »  



Laura Poliseno
18 September 2012: re5.
Pseudogenes can have multiple, diverse functions, affecting not only their parental genes but also unrelated genes. Gloss »   Abstract »   Full Text »   PDF »  


Research Resources

Nicholas T. Woods, Rafael D. Mesquita, Michael Sweet, Marcelo A. Carvalho, Xueli Li, Yun Liu, Huey Nguyen, C. Eric Thomas, Edwin S. Iversen, Jr., Sylvia Marsillac, Rachel Karchin, John Koomen, and Alvaro N. A. Monteiro
18 September 2012: rs6.
Building a protein-protein interaction network mediated by the BRCT domain reveals players in the DNA damage response. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882