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Editors' Choice

John F. Foley
25 September 2012: ec249.
Invariant natural killer T cells produce anti-inflammatory cytokines in the adipose tissue and protect against diet-induced obesity. Abstract »  
Nancy R. Gough
25 September 2012: ec250.
Neutrophils secrete elastase, which not only recruits other immune cells but also inhibits insulin signaling in adipose and liver. Abstract »  
Nancy R. Gough
25 September 2012: ec251.
Reversible phosphorylation of cysteine regulates the DNA binding activity of a virulence protein in Staphylococcus aureus. Abstract »  
Wei Wong
25 September 2012: ec252.
In Caenorhabditis elegans, hydrogen peroxide can stimulate the transcriptional activation of genes involved in lipid biosynthesis. Abstract »  


Research Articles

Tomonori Kaneko, Haiming Huang, Xuan Cao, Xing Li, Chengjun Li, Courtney Voss, Sachdev S. Sidhu, and Shawn S. C. Li
25 September 2012: ra68.
Engineered SH2 domains with high affinity for phosphorylated tyrosine inhibit cell signaling downstream of receptor tyrosine kinases. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Junji Yamauchi, Yuki Miyamoto, Tomohiro Torii, Shou Takashima, Kazumi Kondo, Katsumasa Kawahara, Noriko Nemoto, Jonah R. Chan, Gozoh Tsujimoto, and Akito Tanoue
25 September 2012: ra69.
Transgenic and knockout mice reveal a pathway that controls the extent of myelination by Schwann cells. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Ulrich Putz, Jason Howitt, Anh Doan, Choo-Peng Goh, Ley-Hian Low, John Silke, and Seong-Seng Tan
25 September 2012: ra70.
A tumor suppressor protein with lipid phosphatase activity is carried to target cells in microvesicles. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Niall J. Haslam and Denis C. Shields
25 September 2012: pe40.
Engineered high-affinity SH2 domains inhibit signaling and may be evolutionarily unfavorable. Abstract »   Full Text »   PDF »  
Nancy L. Lill and Nurettin Ilter Sever
25 September 2012: pe41.
Trafficking of activated epidermal growth factor receptors controls the transcriptional response to this oncogenic pathway. Abstract »   Full Text »   PDF »  
Graham Carpenter and Ambra Pozzi
25 September 2012: pe42.
Proteolysis of receptor tyrosine kinases produces intracellular fragments with distinct roles in growth factor signaling. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882