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Cover Figure

ONLINE COVER This week features a Research Article (see also the Perspective) about Vav2 and Vav3, which are guanine nucleotide exchange factors for the Rho family of guanosine triphosphatases, and how targeting these two Vav isoforms could prevent breast tumors from metastasizing to the lung. The image shows a lung tumor formed from metastasizing breast cancer cells. [Image: Carmen Citterio and Mauricio Menacho-Márquez/Centro de Investigación del Cáncer/Cancer Research Center of Salamanca]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882