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Editors' Choice

Nancy R. Gough
2 October 2012: ec253.
Antagonism of TRPV4 channels contributes to the browning of white adipose tissue. Abstract »  
John F. Foley
2 October 2012: ec254.
Mice lacking Rho-associated kinase have impaired sensitivity to the appetite-suppressing hormone leptin. Abstract »  
Ernesto Andrianantoandro
2 October 2012: ec255.
Accumulation of a cholesterol precursor promotes lipid homeostasis and prevents inflammatory responses in macrophages. Abstract »  
Wei Wong
2 October 2012: ec256.
Hedgehog signaling in mesenchymal cell clusters dictates formation of villi from the intestinal epithelium. Abstract »  
L. Bryan Ray
2 October 2012: ec257.
Polyploid cancer cells trigger an immune response owing to proteins aberrantly exposed on their outer surfaces. Abstract »  
Kristen L. Mueller
2 October 2012: ec258.
A mutation that accounts for adverse reactions to the Bacille Calmette-Guérin vaccine against tuberculosis is identified. Abstract »  


Research Articles

Carmen Citterio, Mauricio Menacho-Márquez, Ramón García-Escudero, Romain M. Larive, Olga Barreiro, Francisco Sánchez-Madrid, Jesús M. Paramio, and Xosé R. Bustelo
2 October 2012: ra71.
Two Vav isoforms could be targeted to prevent breast tumors from metastasizing to the lung. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Qian-Feng Li, Chunming Wang, Lei Jiang, Shuo Li, Samuel S. M. Sun, and Jun-Xian He
2 October 2012: ra72.
Crosstalk between two signaling pathways that control plant growth occurs through the DELLA family of transcription factors. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Laura Barrio-Real and Marcelo G. Kazanietz
2 October 2012: pe43.
The guanine exchange factors Vav2 and Vav3 regulate gene expression to promote the metastasis of breast tumors to the lung. Abstract »   Full Text »   PDF »  
Mala M. Shah
2 October 2012: pe44.
Reduced function of hyperpolarization-activated cyclic nucleotide-gated channels alleviates depressive-like behavior in rodents. Abstract »   Full Text »   PDF »  
Hymie Anisman and Shawn Hayley
2 October 2012: pe45.
Manipulation of pro- and anti-inflammatory mediators may improve treatments for depression. Abstract »   Full Text »   PDF »  



Tomoshige Kino
2 October 2012: pt4.
The circadian clock cooperates with the hypothalamic-pituitary-adrenal axis to control tissue sensitivity to diurnally fluctuating circulating glucocorticoids. Abstract »   Full Text »   PDF »   Slideshow »  
Evangelia Charmandari
2 October 2012: pt5.
Distinct activities of glucocorticoid receptor variants and isoforms should be considered in the management of pathologic conditions treated with glucocorticoids. Abstract »   Full Text »   PDF »   Slideshow »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882