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Editors' Choice

Annalisa M. VanHook
9 October 2012: ec259.
Age-related decreases in the proliferative capacity of epidermal stem cells may result from inflammation. Abstract »  
Kristen L. Mueller
9 October 2012: ec260.
Repair of the intestinal epithelium requires both cell proliferation and replacement of crypt stem cells. Abstract »  
Wei Wong
9 October 2012: ec261.
A taste receptor complex acts as an amino acid sensor for mTORC1. Abstract »  
John F. Foley
9 October 2012: ec262.
In mice, activation of an inflammasome triggers the production of eicosanoids, signaling lipids that stimulate inflammation and vascular permeability. Abstract »  
Nancy R. Gough
9 October 2012: ec263.
Binding of the seventh zinc finger of A20 to linear ubiquitin chains is another mechanism by which A20 inhibits activation of nuclear factor {kappa}B. Abstract »  
Peter R. Stern
9 October 2012: ec264.
Morphine reward is modulated by ventral tegmental area BDNF in a way that is opposite to its modulation of cocaine reward. Abstract »  
Peter R. Stern
9 October 2012: ec265.
Deficiency or mutation of the postsynaptic adhesion protein Neuroligin-3 may contribute to cognitive defects in autism. Abstract »  



Eric J. Nestler and Annalisa M. VanHook
9 October 2012: pc22.
The neurotrophic factor BDNF has opposite effects on cocaine- and morphine-induced neuroplasticity. Abstract »   Full Text »   Podcast »  


Research Articles

Kei Miyakawa, Tatsuya Sawasaki, Satoko Matsunaga, Andrey Tokarev, Gary Quinn, Hirokazu Kimura, Masako Nomaguchi, Akio Adachi, Naoki Yamamoto, John Guatelli, and Akihide Ryo
9 October 2012: ra73.
HIV-infected cells dephosphorylate and inactivate a viral factor to restrict viral spreading. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Ágnes Garai, András Zeke, Gergo Gógl, Imre Töro, Ferenc Fördos, Hagen Blankenburg, Tünde Bárkai, János Varga, Anita Alexa, Dorothea Emig, Mario Albrecht, and Attila Reményi
9 October 2012: ra74.
Three related kinases use distinct structural features to discriminate between linear docking motifs in potential binding partners. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



9 October 2012: er6.
Figure 6 and Figure 8, and their legends, are updated to clearly show noncontiguous lanes in immunoblotting data. Full Text »   PDF »  



Panagiota Pervanidou and George P. Chrousos
9 October 2012: pt6.
Trauma-induced changes in circulating cortisol concentrations are associated with pediatric PTSD. Abstract »   Full Text »   PDF »   Slideshow »  
Claudia Buss, Sonja Entringer, and Pathik D. Wadhwa
9 October 2012: pt7.
Intrauterine stress and maternal obesity are associated with neurodevelopmental disorders. Abstract »   Full Text »   PDF »   Slideshow »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882