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Editors' Choice

Nancy R. Gough
23 October 2012: ec272.
Mitochondria isolated from rat brain have NMDA-type glutamate receptors that appear to enhance mitochondrial calcium buffering capacity. Abstract »  
Pamela J. Hines
23 October 2012: ec273.
The plant hormone ethylene triggers cleavage and translocation to the nucleus of a signaling component. Abstract »  
John F. Foley
23 October 2012: ec274.
Proinflammatory cytokines cause tumor cells to lose the markers that make them targets of antitumor cytotoxic T cells. Abstract »  
Ernesto Andrianantoandro
23 October 2012: ec275.
Noncanonical Hedgehog signaling increases glucose metabolism in muscle and brown fat. Abstract »  
Paula A. Kiberstis
23 October 2012: ec276.
The mammalian circadian clock controls the daily oscillation of transcript abundance through both transcriptional and posttranscriptional events, and an RNA-binding protein links changes in body temperature to the mammalian circadian clock. Abstract »  



Stephen D. Nimer and Annalisa M. VanHook
23 October 2012: pc23.
A progrowth signal can mediate feedback that reduces cell proliferation and stem cell self-renewal. Abstract »   Full Text »   Podcast »  


Research Articles

Yan Liu, Fan Liu, Hao Yu, Xinyang Zhao, Goro Sashida, Anthony Deblasio, Michael Harr, Qing-Bai She, Zhenbang Chen, Hui-Kuan Lin, Silvana Di Giandomenico, Shannon E. Elf, Youyang Yang, Yasuhiko Miyata, Gang Huang, Silvia Menendez, Ingo K. Mellinghoff, Neal Rosen, Pier Paolo Pandolfi, Cyrus V. Hedvat, and Stephen D. Nimer
23 October 2012: ra77.
Akt counteracts growth-promoting signals by stimulating the transcription of tumor suppressor genes. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Rui Kang and Daolin Tang
23 October 2012: pe47.
The RNA-dependent protein kinase activates the inflammasome to promote inflammation. Abstract »   Full Text »   PDF »  



Lars Sävendahl
23 October 2012: pt9.
The glucocorticoids and inflammatory cytokines induced by stress can impair bone growth. Abstract »   Full Text »   PDF »   Slideshow »  
M. Loredana Marcovecchio and Francesco Chiarelli
23 October 2012: pt10.
Stress-induced hormonal changes alter glucose homeostasis in both diabetic and healthy patients. Abstract »   Full Text »   PDF »   Slideshow »  
Walter L. Miller
23 October 2012: pt11.
Mutant forms of an enzyme required for steroid synthesis and drug metabolism result in a range of clinical symptoms. Abstract »   Full Text »   PDF »   Slideshow »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882