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Cover Figure

ONLINE COVER This week features a Research Article that suggests a role for G6b-B, a receptor that contains inhibitory motifs, in regulating the function of megakaryocytes, which produce platelets. Compared to wild-type mice, mice deficient in G6b-B produce larger, fewer, and less functional platelets, leading to macrothrombocytopenia and a bleeding disorder. The image shows two megakaryocytes near the center of a section of bone marrow. [Image: Wbensmith/Wikimedia Commons]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882