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Editors' Choice

John F. Foley
30 October 2012: ec277.
A phosphatase-containing complex inhibits NF-{kappa}B signaling in T cells. Abstract »  
Nancy R. Gough
30 October 2012: ec278.
The adaptor Bam32 mediates a pathway involving phospholipase C and the kinase Pak to activate the MAPK pathway independently of guanosine triphosphatases. Abstract »  
Annalisa M. VanHook
30 October 2012: ec279.
A neuropeptide related to oxytocin and vasopressin controls mating behavior and associative learning in nematodes. Abstract »  
Pamela J. Hines
30 October 2012: ec280.
A protein in a hippocampal postsynaptic neuron templates transmitter release kinetics in its presynaptic neuron. Abstract »  
Annalisa M. VanHook
30 October 2012: ec281.
A protein implicated in inherited ciliopathies recruits Smoothened to a ciliary microdomain and is required for Hedgehog signaling. Abstract »  
Ernesto Andrianantoandro
30 October 2012: ec282.
Innate immunity signals enable exogenously delivered transcription factors to induce pluripotency. Abstract »  
Stella M. Hurtley
30 October 2012: ec283.
The protein XErp1 regulates cell cycle progression in frog embryos by inhibiting the anaphase-promoting complex/cyclosome. Abstract »  



Yotis A. Senis and Annalisa M. VanHook
30 October 2012: pc24.
Mice lacking an inhibitory receptor have defects in the number, size, and function of platelets. Abstract »   Full Text »   Podcast »  


Research Articles

Alexandra Mazharian, Ying-Jie Wang, Jun Mori, Danai Bem, Brenda Finney, Silke Heising, Paul Gissen, James G. White, Michael C. Berndt, Elizabeth E. Gardiner, Bernhard Nieswandt, Michael R. Douglas, Robert D. Campbell, Steve P. Watson, and Yotis A. Senis
30 October 2012: ra78.
An inhibitory receptor ensures that megakaryocytes produce proper numbers of functional platelets. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  


Meeting Reports

Evangelia Charmandari, John C. Achermann, Jean-Claude Carel, Olle Soder, and George P. Chrousos
30 October 2012: mr1.
Endocrine and inflammatory responses to stress affect many aspects of development, physiology, and cognition. Abstract »   Full Text »   PDF »  



Sonja Entringer, Claudia Buss, and Pathik D. Wadhwa
30 October 2012: pt12.
Telomere biology may mediate the effects of intrauterine stress on subsequent newborn, child, and adult health and disease risk outcomes. Abstract »   Full Text »   PDF »   Slideshow »  
Eleni Katsantoni
30 October 2012: pt13.
Identification of a transcription factor’s interacting partners and target genes can reveal context-specific signaling and transcriptional outputs. Abstract »   Full Text »   PDF »   Slideshow »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882