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Editors' Choice

John F. Foley
6 November 2012: ec284.
In estrogen receptor–dependent breast cancer cells, estrogen signaling antagonizes the proapoptotic function of the tumor suppressor p53. Abstract »  
Stella M. Hurtley
6 November 2012: ec285.
Protein degradation helps to coordinate the growth of chloroplasts with that of the whole plant. Abstract »  
Pamela J. Hines
6 November 2012: ec286.
Cochliobolus victoriae, a necrotrophic fungal pathogen with devastating effects on oat crops, reveals its strategies. Abstract »  
Nancy R. Gough
6 November 2012: ec287.
Serine phosphorylation of the neurotrophin receptor TrkB by Cdk5 contributes to synaptic plasticity and memory in mice. Abstract »  
Ernesto Andrianantoandro
6 November 2012: ec288.
AATF (apoptosis-antagonizing transcription factor) promotes activation of c-Jun to drive apoptosis. Abstract »  



Michael A. Frohman and Annalisa M. VanHook
6 November 2012: pc25.
A lipid signaling enzyme promotes the growth, vascularization, and metastasis of tumors in mice. Abstract »   Full Text »   Podcast »  


Research Articles

Qin Chen, Tsunaki Hongu, Takanobu Sato, Yi Zhang, Wahida Ali, Julie-Ann Cavallo, Adrianus van der Velden, Huasong Tian, Gilbert Di Paolo, Bernhard Nieswandt, Yasunori Kanaho, and Michael A. Frohman
6 November 2012: ra79.
Genetic ablation or pharmacological inhibition of a lipid signaling enzyme attenuates tumor growth and metastasis. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Chintan K. Kikani, Erik V. Verona, Jiyoon Ryu, Yanying Shen, Qingqing Ye, Li Zheng, Ziliang Qian, Hiroshi Sakaue, Kyoko Nakamura, Jie Du, Qunsheng Ji, Wataru Ogawa, Lu-Zhe Sun, Lily Q. Dong, and Feng Liu
6 November 2012: ra80.
PDK1 in the nucleus drives oncogenesis in mice and correlates with human prostate tumor grade. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Claudio W. Pikielny
6 November 2012: pe48.
DEG/ENaC channels allow male fruit flies to "taste" their mates. Abstract »   Full Text »   PDF »  
Artur A. Belov and Moosa Mohammadi
6 November 2012: pe49.
The adaptor Grb2 plays both positive and negative roles in FGF receptor signaling. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882