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Cover Figure

ONLINE COVER This week features a Research Article describing how two single amino acid changes enable the adaptor protein TRAF5 to acquire the TRAF3-like ability to bind to Cardif, a component of a viral response pathway, and thus promote the production of interferon. The image shows the TRAF domain of TRAF3 bound to Cardif. [Image: Chris Bickel/AAAS]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882