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Editors' Choice

Wei Wong
13 November 2012: ec289.
Toll-like receptor 2 promotes tumorigenesis in a mouse model of gastric cancer, but not by enhancing inflammation. Abstract »  
Ernesto Andrianantoandro
13 November 2012: ec290.
Regulation of a soluble inhibitor of the cytokine IL-22 is key to enabling tissue repair but preventing tumorigenesis. Abstract »  
John F. Foley
13 November 2012: ec291.
Combined targeting of the receptors HER2 and VEGFR delays the growth of HER2-positive breast cancer metastases in mouse brain. Abstract »  
Kristen L. Mueller
13 November 2012: ec292.
Tagging adenovirus with a serum protein prompts an immune response when the virus enters cells. Abstract »  
Nancy R. Gough
13 November 2012: ec293.
The poly(ADP-ribose) polymerase PARP16 modifies two kinases involved in the unfolded protein response pathway to enhance their activity. Abstract »  
Stella M. Hurtley
13 November 2012: ec294.
Protein misfolding stimulates the destruction of microRNAs and the synthesis of an enzyme that promotes cell death. Abstract »  
Nancy R. Gough
13 November 2012: ec295.
Nucleocytoplasmic shuttling of the catalytically inactive histone deacetylase HDAC4 is important for memory. Abstract »  

 

Research Articles

Peng Zhang, Anna Reichardt, Huanhuan Liang, Roghiyh Aliyari, David Cheng, Yaya Wang, Feng Xu, Genhong Cheng, and Yingfang Liu
13 November 2012: ra81.
Two single amino acid changes enable the adaptor protein TRAF5 to promote antiviral responses. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Annemiek B. van Spriel, Sandra de Keijzer, Alie van der Schaaf, Kate H. Gartlan, Mariam Sofi, Amanda Light, Peter C. Linssen, Jan B. Boezeman, Malou Zuidscherwoude, Inge Reinieren-Beeren, Alessandra Cambi, Fabienne Mackay, David M. Tarlinton, Carl G. Figdor, and Mark D. Wright
13 November 2012: ra82.
Antibody-producing B cells require CD37-dependent integrin signaling for long-term survival. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Nick R. Leslie
13 November 2012: pe50.
Transfer of PTEN between cells has potential as an intercellular form of tumor suppression. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882