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Editors' Choice

Wei Wong
20 November 2012: ec296.
Promoting angiogenesis may increase recovery of motor function in individuals with multiple sclerosis. Abstract »  
Ernesto Andrianantoandro
20 November 2012: ec297.
The oxidation state of hemoglobin α in myoendothelial junctions controls delivery of nitric oxide. Abstract »  
Annalisa M. VanHook
20 November 2012: ec298.
Dishevelled inhibits Notch signaling by preventing the formation of transcriptional activator complexes. Abstract »  
Nancy R. Gough
20 November 2012: ec299.
SUMOylation of the guanosine triphosphatase ARL13B is required for proper targeting of sensory receptors into primary cilia. Abstract »  
Nancy R. Gough
20 November 2012: ec300.
The kinase IKK{varepsilon} promotes oncogenic signaling by phosphorylating the adaptor TRAF2. Abstract »  
L. Bryan Ray
20 November 2012: ec301.
A direct link between a cancer-promoting protein kinase and the control of autophagy is presented. Abstract »  



Robert J. Lefkowitz and Annalisa M. VanHook
20 November 2012: pc26.
The 2012 Nobel Prize in Chemistry honors research on the function of G protein–coupled receptors. Abstract »   Full Text »   Podcast »  


Research Articles

Minsoo Choi, Jue Shi, Sung Hoon Jung, Xi Chen, and Kwang-Hyun Cho
20 November 2012: ra83.
State-space analysis of the p53 network identifies a therapeutic strategy for treating cancer. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Leigh D. Plant, Leandro Zuniga, Dan Araki, Jeremy D. Marks, and Steve A. N. Goldstein
20 November 2012: ra84.
Potassium channels that respond to acidification and the anesthetic halothane become electrically silenced when SUMOylated. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Yeon-Jeong Kim, Takamitsu Sano, Takuji Nabetani, Yoshimi Asano, and Yoshio Hirabayashi
20 November 2012: ra85.
Mice lacking an orphan G protein–coupled receptor show reduced inflammatory signaling and obesity. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



J. Robert Lane and Meritxell Canals
20 November 2012: pe51.
Fluorescent probes reveal the roles of domain rearrangement and dimerization in GPCR activation. Abstract »   Full Text »   PDF »  
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