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Editors' Choice

John F. Foley
27 November 2012: ec302.
A receptor that binds to extracellular ceramide inhibits mast cell activation and allergic responses in vivo. Abstract »  
Wei Wong
27 November 2012: ec303.
The bacterial protein flagellin can promote allergic asthma by activating Toll-like receptor 5. Abstract »  
Pamela J. Hines
27 November 2012: ec304.
The cysteine-rich proteins of Arabidopsis egg and central cells enable fusion with just one sperm each. Abstract »  
Annalisa M. VanHook
27 November 2012: ec305.
A protein that promotes NF-{kappa}B signaling during the immune response is also required for phagocytosis independently of NF-{kappa}B. Abstract »  
Paula A. Kiberstis
27 November 2012: ec306.
A metabolite is identified that may help cancer cells coordinate their mode of energy generation with nutrient conditions. Abstract »  



Rose Zamoyska and Annalisa M. VanHook
27 November 2012: pc27.
A phosphatase implicated in autoiummunity modulates the activities of both effector and regulatory T cells. Abstract »   Full Text »   Podcast »  


Research Articles

Willem-Jan Keune, David R. Jones, Yvette Bultsma, Lilly Sommer, Xiao Zhen Zhou, Kun Ping Lu, and Nullin Divecha
27 November 2012: ra86.
Increasing the abundance of the phospholipid PtdIns5P protects cells from oxidative stress. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Rebecca J. Brownlie, Lisa A. Miosge, Demetrios Vassilakos, Lena M. Svensson, Andrew Cope, and Rose Zamoyska
27 November 2012: ra87.
Loss of the phosphatase PTPN22 enhances the functions of both effector and regulatory T cells. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Jeffrey D. Axelrod
27 November 2012: pe52.
Imaging, modeling, and genetics reveal the roles of an atypical myosin in morphogenesis. Abstract »   Full Text »   PDF »  



27 November 2012: er7.
A typographical error in the name of a medical condition described on Slide 9 is corrected. Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882