27 November 2012
Vol 5, Issue 252

About The Cover

Cover image expansion

Online Cover This week features a Research Article that shows that loss of the cytoplasmic phosphatase PTPN22 in mice enhances the strength of responses of effector T cells as well as the immunosuppressive function of regulatory T cells. The image shows histological analysis of a section of intestine from a mouse in which colitis was induced by the transfer of PTPN22-deficient T cells. [Image: Rebecca Brownlie, Institute for Immunology and Infection Research, The University of Edinburgh, UK]