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Cover Figure

ONLINE COVER This week features a Research Article that shows that loss of the cytoplasmic phosphatase PTPN22 in mice enhances the strength of responses of effector T cells as well as the immunosuppressive function of regulatory T cells. The image shows histological analysis of a section of intestine from a mouse in which colitis was induced by the transfer of PTPN22-deficient T cells. [Image: Rebecca Brownlie, Institute for Immunology and Infection Research, The University of Edinburgh, UK]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882