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Editors' Choice

Leslie K. Ferrarelli
4 December 2012: ec307.
Specific forms of vitamin B produced by microbes are recognized by the antigen-presenting receptor MR1 and activate the immune response in the gut. Abstract »  
John F. Foley
4 December 2012: ec308.
Estrogen signaling suppresses the growth of hepatocellular carcinoma by preventing alternative activation of tumor-associated macrophages. Abstract »  
Wei Wong
4 December 2012: ec309.
MED12 inhibits TGF-β signaling through a nontranscriptional mechanism. Abstract »  
Ernesto Andrianantoandro
4 December 2012: ec310.
Akt promotes its own expression, cell survival, and tumorigenicity in embryonal carcinoma cells by phosphorylating Oct4. Abstract »  
Nancy R. Gough
4 December 2012: ec311.
An increase in 14-3-3 proteins switches axons from being attracted to being repulsed by Sonic hedgehog. Abstract »  
Annalisa M. VanHook
4 December 2012: ec312.
An EGF repeat in the extracellular domain of Notch allows this receptor to discriminate between ligands. Abstract »  
Laura Zahn
4 December 2012: ec313.
Parental genetic conflict may have exploited changes in the coding of a protein loop in a growth factor receptor. Abstract »  


Research Articles

Catherine M. Guzzo, Christopher E. Berndsen, Jianmei Zhu, Vibhor Gupta, Ajit Datta, Roger A. Greenberg, Cynthia Wolberger, and Michael J. Matunis
4 December 2012: ra88.
DNA repair proteins find sites of damage marked by hybrid SUMO-ubiquitin chains. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Hashem A. Dbouk, Oscar Vadas, Aliaksei Shymanets, John E. Burke, Rachel S. Salamon, Bassem D. Khalil, Mathew O. Barrett, Gary L. Waldo, Chinmay Surve, Christine Hsueh, Olga Perisic, Christian Harteneck, Peter R. Shepherd, T. Kendall Harden, Alan V. Smrcka, Ronald Taussig, Anne R. Bresnick, Bernd Nürnberg, Roger L. Williams, and Jonathan M. Backer
4 December 2012: ra89.
Blocking the activation of p110β by G proteins inhibits tumor cell proliferation. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Felipe O. Bendezú and Sophie G. Martin
4 December 2012: pe53.
Oscillations in the localization of active Cdc42 govern polarized cell growth in yeasts. Abstract »   Full Text »   PDF »  



Luca Busino, Scott E. Millman, and Michele Pagano
4 December 2012: pt14.
Ubiquitin-mediated degradation of an inhibitor of noncanonical NF-{kappa}B signaling promotes cell survival. Abstract »   Full Text »   PDF »   Slideshow »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882