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Cover Figure

ONLINE COVER This week features a Research Article that characterizes the mechanism by which the p110β isoform of the kinase PI3K is activated by Gβγ subunits downstream of G protein–coupled receptors (GPCRs). The p110β isoform can also be activated by receptor tyrosine kinases (RTKs), and work in this study generated a peptide that specifically inhibited the activation of p110β by GPCRs but not by RTKs. The image shows the structures of p110β and Gβγ associated with a lipid bilayer, with the Gβγ dimer in red and yellow and the Gβγ-binding region of p110β in blue. [Image: Oscar Vadas, MRC Laboratory of Molecular Biology, Cambridge, UK]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882