Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Cover Figure

ONLINE COVER This week features a Research Article that characterizes the mechanism by which the p110β isoform of the kinase PI3K is activated by Gβγ subunits downstream of G protein–coupled receptors (GPCRs). The p110β isoform can also be activated by receptor tyrosine kinases (RTKs), and work in this study generated a peptide that specifically inhibited the activation of p110β by GPCRs but not by RTKs. The image shows the structures of p110β and Gβγ associated with a lipid bilayer, with the Gβγ dimer in red and yellow and the Gβγ-binding region of p110β in blue. [Image: Oscar Vadas, MRC Laboratory of Molecular Biology, Cambridge, UK]

[Table of Contents]

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882