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Editors' Choice

Annalisa M. VanHook
18 December 2012: ec324.
A developmental timing program is redeployed to extend life span in the absence of a germ line. Abstract »  
Leslie K. Ferrarelli
18 December 2012: ec325.
Rotavirus initiates, but blocks completion of, autophagy to replicate and assemble new viral particles. Abstract »  
Nancy R. Gough
18 December 2012: ec326.
A noncanonical pathway involving the adaptor MyD88 may contribute to the disruption of endothelial barrier function associated with inflammation. Abstract »  
Sacha N. Vignieri
18 December 2012: ec327.
A male sex pheromone rapidly stimulates learning of place preference that is remembered for about 2 weeks. Abstract »  
Nancy R. Gough
18 December 2012: ec328.
The more neuroligin-1 present, the more likely a synapse is to form. Abstract »  


Research Articles

Valentina Evdokimova, Cristina E. Tognon, Tania Benatar, Wenyi Yang, Konstantin Krutikov, Michael Pollak, Poul H. B. Sorensen, and Arun Seth
18 December 2012: ra92.
By inactivating the insulin-like growth factor receptor, IGFBP7 suppresses growth and promotes cell death. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Xuehua Piao, Sachiko Komazawa-Sakon, Takashi Nishina, Masato Koike, Jiang-Hu Piao, Hanno Ehlken, Hidetake Kurihara, Mutsuko Hara, Nico Van Rooijen, Günther Schütz, Masaki Ohmuraya, Yasuo Uchiyama, Hideo Yagita, Ko Okumura, You-Wen He, and Hiroyasu Nakano
18 December 2012: ra93.
The antiapoptotic protein c-FLIP blocks multiple cell death pathways in mice. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Dorothy Koveal, Natasha Schuh-Nuhfer, Daniel Ritt, Rebecca Page, Deborah K. Morrison, and Wolfgang Peti
18 December 2012: ra94.
A previously unknown module that mediates membrane binding is identified in the scaffold KSR. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Garif Yalak and Viola Vogel
18 December 2012: re7.
Proteomic data indicate that the phosphorylation of extracellular proteins and extracellular protein domains is a widespread phenomenon. Gloss »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882