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Editors' Choice

Annalisa M. VanHook
8 January 2013: ec5.
Independently of its protease activity, a metalloproteinase cooperates with an integrin to promote mammary epithelial tube branching. Abstract »  
John F. Foley
8 January 2013: ec6.
Orthologs of the mammalian nutrient sensor AMPK inhibit Hippo signaling in Drosophila. Abstract »  
Leslie K. Ferrarelli
8 January 2013: ec7.
Sequestered microRNAs serve as a regulatory reserve pool to enable quiescent cells to effectively respond to mitogenic signals. Abstract »  
Wei Wong
8 January 2013: ec8.
Ca2+ promotes the tyrosine phosphorylation of CD3 in stimulated T cells by displacing it from the plasma membrane. Abstract »  
Nancy R. Gough
8 January 2013: ec9.
Two opposing signals controlling endothelial cell permeability converge on the Rho guanine nucleotide exchange factor Syx. Abstract »  


Research Articles

Yixin Yao, Milind Suraokar, Bryant G. Darnay, Brett G. Hollier, Tattym E. Shaiken, Takayuki Asano, Chien-Hung Chen, Benny H.-J. Chang, Yiling Lu, Gordon B. Mills, Dos Sarbassov, Sendurai A. Mani, James L. Abbruzzese, and Shrikanth A. G. Reddy
8 January 2013: ra2.
Activation of Akt1 during adipocyte differentiation requires a binding partner called BSTA. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Wei-Lei Yang, Guoxiang Jin, Chien-Feng Li, Yun Seong Jeong, Asad Moten, Dazhi Xu, Zizhen Feng, Wei Chen, Zhen Cai, Bryant Darnay, Wei Gu, and Hui-Kuan Lin
8 January 2013: ra3.
The deubiquitinase CYLD suppresses activation of the tumor growth–promoting kinase Akt. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Kui Lin
8 January 2013: pe1.
Deubiquitination limits the kinase activity of Akt in the absence of growth factor stimulation. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882