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Editors' Choice

Nancy R. Gough
15 January 2013: ec10.
Mice deficient in the ligand Mfge8, an integrin-binding protein, have enhanced contractility of airway smooth muscle cells. Abstract »  
Kristen L. Mueller
15 January 2013: ec11.
A kinase in macrophages is required for high-fat diet–induced metabolic changes and inflammation. Abstract »  
Leslie K. Ferrarelli
15 January 2013: ec12.
The mechanism that induces an antitumor immune response from 5-fluorouracil and gemcitabine also initiates protumorigenic inflammation. Abstract »  
Wei Wong
15 January 2013: ec13.
A transcription factor promotes the metastasis of nonaggressive PTEN-null prostate tumors through a nontranscriptional mechanism. Abstract »  
Annalisa M. VanHook
15 January 2013: ec14.
Carnivorous fungi identify prey by intercepting pheromone communication. Abstract »  
Annalisa M. VanHook
15 January 2013: ec15.
Yeast use a wandering polarity patch to track chemical gradients and identify appropriate mating partners. Abstract »  
L. Bryan Ray
15 January 2013: ec16.
Ketone bodies, metabolites that accumulate during fasting, change gene expression by inhibiting histone deacetylases. Abstract »  
Peter R. Stern
15 January 2013: ec17.
The expression of metabotropic glutamate receptors in brain astrocytes is down-regulated in early postnatal development. Abstract »  
John F. Foley
15 January 2013: ec18.
Whereas Cullin3-mediated ubiquitylation of caspase-8 promotes its activation, ubiquitylation by TRAF2 promotes its degradation. Abstract »  

 

Editorial Guides

John F. Foley
15 January 2013: eg2.
Inflammatory responses can be both beneficial and detrimental. Abstract »   Full Text »   PDF »  

 

Podcasts

Gabriel Núñez and Annalisa M. VanHook
15 January 2013: pc2.
Identification of inflammatory response regulators sheds light on disease. Abstract »   Full Text »   Podcast »  

 

Perspectives

John Silke and Andreas Strasser
15 January 2013: pe2.
The protein c-FLIP plays a role in preventing cell death by both apoptosis and necroptosis. Abstract »   Full Text »   PDF »  
Lawrence Steinman
15 January 2013: pe3.
Four cytokines play complex roles in neuroinflammatory diseases. Abstract »   Full Text »   PDF »  

 

Research Resources

Ulrich auf dem Keller, Anna Prudova, Ulrich Eckhard, Barbara Fingleton, and Christopher M. Overall
15 January 2013: rs2.
Quantitative proteomic analysis of inflamed mouse skin reveals mediators of the inflammatory response in vivo. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Neil Warner, Aaron Burberry, Luigi Franchi, Yun-Gi Kim, Christine McDonald, Maureen A. Sartor, and Gabriel Núñez
15 January 2013: rs3.
A small interfering RNA screen provides insight into the mechanisms of Crohn’s disease pathogenesis. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882