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Editors' Choice

Nancy R. Gough
29 January 2013: ec25.
Cultured neurons exhibit reversible Golgi fragmentation. Abstract »  
Stella Hurtley
29 January 2013: ec26.
A model of neurotransmitter release explains why two proteins not needed for membrane fusion in vitro are needed in vivo. Abstract »  
Wei Wong
29 January 2013: ec27.
Loss of the kinase AMPK promotes the Warburg effect in cancer cells. Abstract »  
Nancy R. Gough
29 January 2013: ec28.
Like a radio, the mitogen-activated protein kinase pathway exhibits both frequency and amplitude modulation. Abstract »  
L. Bryan Ray
29 January 2013: ec29.
A yeast protein transforms stress signals into distinct dynamic responses according to the timing and strength of inputs. Abstract »  
Leslie K. Ferrarelli
29 January 2013: ec30.
The receptor PD-1 inhibits follicular regulatory T cell–mediated suppression of antibody production. Abstract »  
John F. Foley
29 January 2013: ec31.
The IKK complex targets the proapoptotic protein BAD to inhibit TNF-induced apoptosis independently of nuclear factor {kappa}B signaling. Abstract »  



Friedegund Meier and Annalisa M. VanHook
29 January 2013: pc3.
Vemurafenib induces endoplasmic reticulum stress in melanoma cells. Abstract »   Full Text »   Podcast »  


Research Articles

Syevda Sirenko, Dongmei Yang, Yue Li, Alexey E. Lyashkov, Yevgeniya O. Lukyanenko, Edward G. Lakatta, and Tatiana M. Vinogradova
29 January 2013: ra6.
Distinctive features in calcium cycling may explain the pacemaker activity of sinoatrial node cells in the heart. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Daniela Beck, Heike Niessner, Keiran S. M. Smalley, Keith Flaherty, Kim H. T. Paraiso, Christian Busch, Tobias Sinnberg, Sophie Vasseur, Juan Lucio Iovanna, Stefan Drießen, Björn Stork, Sebastian Wesselborg, Martin Schaller, Tilo Biedermann, Jürgen Bauer, Konstantinos Lasithiotakis, Benjamin Weide, Jürgen Eberle, Birgit Schittek, Dirk Schadendorf, Claus Garbe, Dagmar Kulms, and Friedegund Meier
29 January 2013: ra7.
Drug resistance in melanomas may be overcome by therapies that trigger endoplasmic reticulum stress. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  


Teaching Resources

B. Ian Hutchins
29 January 2013: tr1.
QR codes can be used to display dynamic data at scientific meetings. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882