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ONLINE COVER This week features a Research Article that indicates that drug resistance in melanomas may be overcome by therapies that trigger endoplasmic reticulum (ER) stress, a form of cellular stress that can culminate in cell death. The image shows melanoma cells with dilated ER, a sign of ER stress. [Image: Daniela Beck, Martin Schaller, and Friedegund Meier, Department of Dermatology, University of Tübingen, Germany]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882