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Editors' Choice

Annalisa M. VanHook
5 February 2013: ec32.
The Hippo and PCP signaling activities of the atypical cadherin Fat rely on different regions of the Fat intracellular domain. Abstract »  
Nancy R. Gough
5 February 2013: ec33.
Knock-in mice reveal a critical role for mTORC1 in stimulating autophagy to survive the hypoglycemic period that follows birth. Abstract »  
Leslie K. Ferrarelli
5 February 2013: ec34.
The pseudokinase TRB3 stimulates pathways promoting Notch-induced breast cancer progression and metastasis. Abstract »  
L. Bryan Ray
5 February 2013: ec35.
A technique for developing specific and potent enzyme inhibitors is validated on enzymes of the ubiquitin-proteasome system. Abstract »  
Annalisa M. VanHook
5 February 2013: ec36.
Computational methods can be used to identify models that are neither too simple nor too complex to be accurate. Abstract »  



Felix Randow and Annalisa M. VanHook
5 February 2013: pc4.
An autophagy receptor specifically targets Salmonella for degradation in infected cells. Abstract »   Full Text »   Podcast »  


Research Articles

Robert B. Hamanaka, Andrea Glasauer, Paul Hoover, Shuangni Yang, Hanz Blatt, Andrew R. Mullen, Spiro Getsios, Cara J. Gottardi, Ralph J. DeBerardinis, Robert M. Lavker, and Navdeep S. Chandel
5 February 2013: ra8.
Skin development requires reactive oxygen species generated by mitochondria in keratinocytes. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Sai Li, Michal P. Wandel, Fudong Li, Zhonghua Liu, Chao He, Jihui Wu, Yunyu Shi, and Felix Randow
5 February 2013: ra9.
A crystal structure of an autophagy receptor with a ligand reveals how Salmonella is specifically targeted for degradation. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Wei Wang
5 February 2013: pe5.
Analysis of network dynamics holds promise for development of novel therapies. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882