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Cover Figure

ONLINE COVER This week features a Research Article (also listen to the accompanying Podcast) describing how HIF-1α inhibits a helicase complex that unwinds DNA in preparation for replication through a nontranscriptional mechanism, thereby inducing cell cycle arrest during hypoxia. The image is an artist's depiction of replicating DNA. [Image: Yana Hammond/Science Signaling]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882