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Editors' Choice

Leslie K. Ferrarelli
12 February 2013: ec37.
Reactive oxygen species produced by NADPH oxidase complex initiates Wnt-mediated regeneration in tadpoles. Abstract »  
Annalisa M. VanHook
12 February 2013: ec38.
Mask acts as a cofactor for transcriptional coactivators in the Hippo pathway to modulate gene transcription. Abstract »  
John F. Foley
12 February 2013: ec39.
Astrocytes suppress neuroinflammation through activation of their dopamine D2 receptors. Abstract »  
Kristen L. Mueller
12 February 2013: ec40.
During inflammation, Escherichia coli uses nitrate respiration to gain a growth advantage over other gut bacteria. Abstract »  
Wei Wong
12 February 2013: ec41.
High glucose concentrations stimulate Wnt signaling by promoting the nuclear accumulation of β-catenin. Abstract »  
Kristen L. Mueller
12 February 2013: ec42.
In mammalian cells, Rap1-interacting factor 1 protects DNA ends against resection. Abstract »  
Kristen L. Mueller
12 February 2013: ec43.
The crystal structure of a viral protein core complex reveals how paramyxoviruses inhibit the innate immune response. Abstract »  
Pamela J. Hines
12 February 2013: ec44.
Specific sugar signals integrate carbohydrate status with day length and developmental age to regulate flowering. Abstract »  

 

Podcasts

Gregg L. Semenza, Maimon E. Hubbi, and Annalisa M. VanHook
12 February 2013: pc5.
In addition to mediating the transcriptional response to hypoxia, HIF-1α also inhibits proliferation under oxygen-limiting conditions. Abstract »   Full Text »   Podcast »  

 

Research Articles

Maimon E. Hubbi, Kshitiz, Daniele M. Gilkes, Sergio Rey, Carmen C. Wong, Weibo Luo, Deok-Ho Kim, Chi V. Dang, Andre Levchenko, and Gregg L. Semenza
12 February 2013: ra10.
In response to hypoxia, HIF-1α induces cell cycle arrest by inhibiting a helicase complex that unwinds DNA in preparation for replication. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Malgorzata Zakrzewska, Ellen Margrethe Haugsten, Beata Nadratowska-Wesolowska, Angela Oppelt, Barbara Hausott, Yixin Jin, Jacek Otlewski, Jørgen Wesche, and Antoni Wiedlocha
12 February 2013: ra11.
Serine phosphorylation limits signaling by a fibroblast growth factor receptor. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Lucy Kotlyanskaya, Kristina A. McLinden, and Edward Giniger
12 February 2013: pe6.
The precursor forms of neurotrophins are functional and mediate opposite signals from the mature forms. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882